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徐淑媛 助理教授

                          徐淑媛(Shu-Yuan Hsu)   

職稱助理教授

研究室名稱細胞生物學實驗室

最高學歷:Ph.D.

學校/國家長庚大學生物醫學研究所/台灣

分機號碼:5088

電子郵件帳號hsusy@mail.cgu.edu.tw

個人網頁網址:

研究室現有: 博士後研究員  

博士班研究生   

碩士班研究生 1

專任研究助理  1 

大學部專題生    

研究方向研究室特色

利用基因工程的方式來研究特定基因在活體內的功能,是現今研究的一個重要工具。然而,除了在生化及生理上的改變之外,目前更重要的趨勢是將其功能與臨床上的病症相結合,以期達到促進健康的終極目標。因此我們利用操縱小鼠基因,並配合斑馬魚的動物模式,除了瞭解特定生理生化上的功能影響之外,我們更著重於觀察因基因改變造成之受損組織或器官所產生的形態上改變。將組織或器官切片,以各種不同方式觀察其型態與特定分子的改變,以期與臨床上的特定病理狀態作結合。

(1)Regulation of angiogenesis in normal development & tumor formation

(2)Effects of melatonin on the proliferation and migration of the breast cancer cells

 

         

 

最近五年所發表論文:

1. Shu-Yuan Hsu, Yen-Jung Chen, and Pin Ouyang (2011) Pnn and SR Family Proteins Are Differentially Expressed in Mouse Central Nervous System. Histochem Cell Biology 135: 361-373 (SCI, CMRPD170073)

2. Shu-Yuan Hsu, Yi-Chuan Cheng, Hung-Yu Shih, and Pin Ouyang (2012) Dissection of the Role of Pinin in the Development of Zebrafish Posterior Pharyngeal Cartilages. Histochem Cell Biology 138: 127-140 (SCI, CMRPD170073)

3. Fan-Yen Lee, Hung-I Lu, Yen-Ti Zhen, Steve Leu, Yubg-Lung Chen, Tzu-Hsien Tsai, Sheng-Ying Chyng, Sarah Chua, Jiunn-Jye Sheu, Shu-Yuan Hsu, Hsueh-Wen Chang, Cheuk-Kwan Sun, Hon-Kan Yip (2013) Benefit of combined therapy with nicorandil and colchicine in preventing monocrotaline-induced rat pulmonary arterial hypertension. European Journal of Pharmaceutical Sciences 50: 372-384 (SCI, CMRPG8A0091)

4. Hsu-Pin Wu*, Shu-Yuan Hsu*, Wen-Ai Wu, Ji-Wei Hu, Pin Ouyang (2014) Transgenic mice expressing mutant Pinin exhibit muscular dystrophy, nebulin deficiency and elevated expression of slow-type muscle fiber genes. Biochemical and Biophysical Research Communications 443: 313-320 (SCI, CMRPD1B0431)

5. Tai-Long Pan, Shu-Yuan Hsu, Pei-Wen Wang, Ya-Ting Cheng, Yu-Chen Chang, Saha Sudipta , Jiwei Hu and Pin Ouyang (2015) FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones. Cell Cycle 14: 1174-1187 (SCI, CMRPD1B0432 and CMRPD1D0341)

6. Cheuk-Kwan Sun, Steve Leu, Shu-Yuan Hsu, Yen-Yi Zhen, Li-The Chang, Chung-Yen Tsai, Yung-Lung Chen, Yen-Ta Chen, Tzu-Hsien Tsai, Fan-Yen Lee, Jiunn-Jye Sheu, Hsueh-Wen Chang, Hon-Kan Yip (2015) Mixed serum-deprived and normal adipose-derived mesenchymal stem cells against acute lung ischemia-reperfusion injury in rats. American Journal of Translational Research 7: 209-231(SCI, CMRPG8A0791)

7. Kun-Chun ChiangHuang-Yang ChenShu-Yuan HsuJong-Hwei S PangShang-Yu WangJun-Te HsuTa-Sen YehLi-Wei ChenSheng-Fong KuoChi-Chin SunJim-Ming LeeChun-Nan YehHorng-Heng Juang (2015) PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Des Devel Ther 9:4631-4638 (SCI, CMRPG2E0031)

8. Ke-Hung Tsui*Shu-Yuan Hsu*Li-Chuan ChungYu-Hsiang LinTsui-Hsia FengTzu-Yi LeePhei-Lang ChangHorng-Heng Juang (2015) Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells.Sci Rep 5:12870 (SCI, CMRPD3E0041, D190613, G3E0151, G392143)

9. Kun-Chun ChiangCho-Li YenChun-Nan YehJun-Te HsuLi-Wei ChenSheng-Fong KuoShang-Yu WangChi-Chin SunAtsushi KittakaTai C ChenTa-Sen YehShu-Yuan Hsu*Horng-Heng Juang* (2015) Hepatocellular carcinoma cells express 25(OH)D-1α-hydroxylase and are able to convert 25(OH)D to 1α,25(OH)2D, leading to the 25(OH)D-induced growth inhibition. J Steroid Biochem Mol Biol 154:47-52 (SCI, CMRPG2A0213, 2A0322, 2A0323)

 

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