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歐陽品 教授

          歐陽品 (Pin Ouyang) 

職稱:解剖科教授兼教務長

研究室名稱:基因工程鼠核心實驗室

最高學歷:Ph.D.

學校/國家:美國哈佛大學

分機號碼X5267

電子郵件帳號 ouyang@mail.cgu.edu.tw

個人網頁網址:

研究室現有: 博士後研究員 1

博士班研究生 1

碩士班研究生 2

專任研究助理 3

大學部專題生

研究方向研究室特色

人類疾病的小鼠動物模式

利用基因工程鼠來探究基因的活體生物功能是現代研究人員必備的研究工具。藉著熟練的大分子DNA克隆及精確控制小鼠的生殖生理學,我們可以隨機操縱小鼠的基因組成分,且可以快速的了解特定基因的組織特異性,並用其製造出人類疾病的動物模式破解特定基因的功能。現階段我們正以基因轉殖鼠及基因剔除鼠的方式,探討與阿滋海莫症 (Alzheimer disease) ,肌肉萎縮症及數個與癌轉移及 DNA複製有關的新型基因,利用製造活體動物的方式提升生物研究的層次及發展治療的應用方法。

A. 阿滋海莫症 (Alzheimer disease)治療及預後研究

(1)阿滋海莫症新藥研發

(2)利用阿滋海莫症小鼠動物模式探討疾病發生的機轉控制

             

缺失pNO40表現的小鼠胚胎腦部脈絡叢 (Chp)有明顯的老化現象(箭頭藍色)

B.再生生物醫學:

Nebulin缺乏肌肉萎縮症 (nemaline myopathy)的病源性及治療方針研究

  缺乏蛋白質表現的小鼠其骨骼肌呈現明顯的肌肉萎縮症狀(圖B, C ,E).

C.癌症生物學

(1)癌症抗原 (cancer/testis antigen) cep55FLJ25439與癌症形成關係及治療

(2) 調控血管新生的抑癌機制

           DSCN5431.JPG

缺乏 Cep55表現的小鼠(右方)只有正常小鼠體型的1/2

最近五年所發表論文 (*責任作者):

1. Hsu S.Y., Y.J. Chen and P. Ouyang* 2011. Pnn and SR family proteins are differentially expressed in mouse central nervous system. Histochem. Cell Biol. 135:361-373. (SCI)

2. Chang Y. C., C.H. Wu, T.C. Yen and P. Ouyang* 2012. Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 protein through polo-like kinase 1 (PLK1). J. Biol. Chem. 287:4376-4385. (SCI)

3. Leu S., Y. M. Lin, C. H. Wu and P. Ouyang* 2012. Loss of pnn expression   results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD. J. Cell Sci. 125:3164-3172. (SCI) Targeted article selected by GlobalMedical Discovery (http//:globalmedicaldiscovery.com)

4. Hsu S.Y., Yi-Chuan Cheng, Hung-Yu Shih and P. Ouyang* 2012. Dissection of the role of   Pinin in the development of zebrafish posterior pharyngeal cartilages. Histochem. Cell Biol. 138:127-140. (SCI)

5. Wu Hsu-Pin, Shu-Yuan Hsu, Wen-Ai Wu, Ji-Wei Hu and P. Ouyang* 2014. Transgenic mice expressing mutant Pinin exhibit muscular dystrophy, nebulin deficiency and elevated expression of slow-type muscle fiber genes. Biochem. Biophys. Res. Com.443: 313-320.

6. Pan T. L., Shu-Yuan Hsu, Pei-Wen Wang, Ya-Ting Cheng, Yu-Cheng Chang, Sudipta Saha, Jiwei Hu and P. Ouyang* 2015. FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosome stability via enhancing expression of endoplasmic reticulum stress chaperones. Cell Cycle 14(8): 1174-87.

7. Lin Y.M., C. C. Wu, Y. C. Chang., C.H. Wu, H.L. Ho, J. W. Hu, R. C. Chang, C.T. Wang and P. Ouyang* 2016. Targeted disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochem. Biophys. Res. Com. 469:903-910.

8. Lin Y.M., Pao-Hsien Chu, Yun-Zhu Li, and P. Ouyang* 2017.Ribosomal protein pNO40 mediates nuceleolar sequestration of SR family splicing factors and its overexpression impairs mRNA metabolism. Cellular Signalling 32;12-23.

9. Shih Hung-Yu, Shu-Hsu Hsu, Pin Ouyang, Sheng-Jia Lin, Ting-Yun Chou, Ming-Chang Chiang, and Yi-Chuan Cheng 2017. Bmp5 regulates neural cell survival and proliferation via tow different signaling pathways. Stem Cells 35:1003-1014.

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